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KMID : 0620920210530061055
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Experimental & Molecular Medicine
2021 Volume.53 No. 6 p.1055 ~ p.1067
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YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior
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Jeon Young-Sic
Yoo Jeong-Eun
Rhee Hyung-Jin
Kim Young-Joo
Kim Gwang-Il
Chung Taek
Yoon Sa-Rah
Shin Bo-Ram
Woo Hyun-Goo
Park Young-Nyun
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Abstract
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The expression of estrogen receptor alpha (ERα, encoded by ESR1) has been shown to be associated with the prognostic outcomes of patients in various cancers; however, its prognostic and mechanistic significance in hepatocellular carcinoma (HCC) remain unclear. Here, we evaluated the expression of ERα and its association with clinicopathological features in 339 HCC patients. ERα was expressed in 9.4% (32/339) of HCCs and was related to better overall survival (OS; hazard ratio [HR]?=?0.11, p?=?0.009, 95% C.I.?=?0.016?0.82) and disease-free survival (DFS, HR?=?0.4, p?=?0.013, 95% C.I.?=?0.18?0.85). ERα expression was also associated with features related to more favorable prognosis, such as older age, lower serum alpha-fetoprotein level, and less microvascular invasion (p?
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KEYWORD
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Gene ontology, Liver cancer, Prognostic markers
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